FRONTLINE COMBO SPOT-ON DOG S 2-10KG 6 PIPETTES

Descriptions
Frontline Combo Spot-On Dog S 2-10Kg 6 Pipettes provides continuous protection thanks to a dual action on fleas: both adults and immature forms (eggs and larvae). Frontline Combo Spot-On Dog S 2-10Kg 6 Pipettes also eliminates ticks.

Descriptions for use, specifying target species
To be used against infestations by fleas alone or mixed infestations by fleas and ticks and/or chewing lice.

Dogs:
- Treatment of flea infestation with ctenocephalides spp. Insecticidal efficacy against new adult flea infestations persists for 8 weeks. Prevents the multiplication of fleas by inhibiting the development of eggs with ovicidal activity and larvae and pupae with larvicidal activity from eggs laid by adult fleas for 8 weeks after application.
- Treatment of infestation by ticks ixodes ricinus, dermacentor variabilis, dermacentor reticulatus, rhipicephalus sanguineus. The product has acaricidal efficacy against ticks that persists for up to 4 weeks.
- Treatment of infestation by chewing lice Trichodectes canis. The product can be incorporated into a treatment programme for flea-bite allergy dermatitis.

Cats:
- Elimination of Ctenocephalides spp. fleas. Insecticidal efficacy against new adult flea infestations persists for 4 weeks.
- Prevention of flea multiplication by inhibiting the development of eggs with ovicidal activity and larvae and pupae with larvicidal activity from eggs laid by adult fleas for 6 weeks after application.
- Elimination of ticks ixodes ricinus, dermacentor variabilis, rhipicephalus sanguineus. The product has acaricidal efficacy against ticks which, according to experimental data, persists for up to 2 weeks.
- Elimination of Felicola subrostratus chewing lice. The drug can be incorporated into a treatment programme for flea allergy dermatitis.

Ferrets:
- For use against infestations by fleas alone or mixed infestations by fleas and ticks.
- Elimination of ctenocephalides spp. Insecticidal efficacy against new infestations by adult fleas persists for 4 weeks. Prevents the multiplication of fleas by inhibiting the development of eggs with ovicidal activity and larvae and pupae with larvicidal activity from eggs laid by adult fleas.
- Eliminates ixodes ricinus ticks. The product has acaricidal efficacy against ticks which persists according to experimental data for 4 weeks.

Directions for use
Applied in one spot to your pet's skin, Frontline Combo Spot-On works in less than 24 hours providing continuous protection. Frontline Combo Spot-On eliminates adult fleas and ticks. Apply to dry skin. It is very important to spread the hair between the shoulders so that the skin is visible: apply the product to the skin, not the hair. The Frontline Combo Spot-On diffuses all over the body and concentrates in the sebaceous glands, which act as a reservoir. Week after week, they release the product, ensuring prolonged efficacy. The product should be applied to the base of the cat's head to prevent the animal from licking it itself. This medicine requires precautions to be taken by the person administering it.

Posology
Cats: the minimum recommended dose is 5 mg of fipronil and 6 mg of S -methoprene per kg of body weight, in one cutaneous application, i.e. a 0.5 ml pipette for a cat. In the absence of tolerance data, the minimum treatment interval is 4 weeks.
Ferrets: One 0.5 ml pipette per ferret, i.e. a dose of 50 mg of fipronil and 60 mg of S -methoprene per ferret, in one cutaneous application. The minimum treatment interval is 4 weeks.
Dogs: the minimum recommended dose is 6.7 mg of fipronil and 6 mg of S -methoprene per kg of body weight, applied to the skin.
Dogs from 2 to 10 kg: one pipette ofFrontline Combo Spot-On Dog S per animal 0.67 ml.
Dogs from 10 to 20 kg: one pipette of Frontline Combo Spot-On Dog M per animal 1.34 ml.
Dogs from 20 to 40 kg: one pipette of Frontline Combo Spot-On Dog L per animal 2.68 ml.
Dogs over 40 kg: one pipette of Frontline Combo Spot-On Dog XL per animal 4.02 ml.
In the absence of tolerance data, the minimum treatment interval is 4 weeks.

Contre-indications
In the absence of available data, do not treat kittens less than 8 weeks old or weighing less than 1 kg. Do not treat ferrets under 6 months of age. Do not treat puppies under 8 weeks of age or weighing less than 2 kg. Do not use on sick animals, for example: systemic diseases, fever or convalescents. Do not use on rabbits, as sometimes lethal side effects may occur. In the absence of studies, use of the product is not recommended for non-target species.
Frontline Combo Spot-On Dog: this product has been specially developed for dogs. Do not use in cats or ferrets as this may lead to an overdose.

Special precautions to be taken by the person administering the veterinary medicine to animals.
This product may cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes. Animals or users with a known hypersensitivity to insecticides or alcohol should avoid contact with the medicine. Avoid contact of contents with fingers. If this occurs, wash hands with soap and water. In the event of accidental exposure to eyes, rinse thoroughly with clean water. Wash hands after use. Do not handle treated animals and do not allow children to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day but rather in the early evening, and that recently treated animals are not allowed to sleep with their owners, especially children. Do not smoke, drink or eat during application.

Adverse reactions (frequency and severity).
Do not overdose.
Cats : Among the very rarely suspected side effects, transient cutaneous reactions at the application site - desquamation, loss of hair, itching, localised redness and generalised itching or loss of hair - have been reported. Excessive salivation, reversible nervous signs, increased sensitivity to stimulation, depression, other nervous signs or vomiting have also been observed after use.
In the event of licking, a brief period of excessive salivation due mainly to the nature of the excipient may be observed.
Dogs: Among the very rarely suspected side effects, transient cutaneous reactions at the application site such as skin discolouration, hair loss, itching, localised redness and generalised itching or hair loss have been reported. Excessive salivation, reversible nervous signs, increased sensitivity to stimulation, depression, other nervous signs or vomiting have also been observed after use. In the case of licking, a brief period of excessive salivation due mainly to the nature of the excipient may be observed.

Use during pregnancy and/or lactation and egg-laying.
Dogs : The speciality may be used during gestation and lactation.
Cats : The product may be used during gestation and lactation.
For treatment during lactation, see ‘Special precautions for use in animals’.
Ferrets : Laboratory studies in cats have not demonstrated teratogenic, foetotoxic or maternotoxic effects. In ferrets, the safety of this veterinary medicinal product has not been tested during gestation and lactation. It should only be used after the veterinarian has assessed the risk/benefit ratio.

Composition
Frontline Combo Spot-On Chat Cat : fipronil 50 mg. s -methoprene 60,0 mg. butylhydroxyanisole e320 0,10 mg. butylhydroxytoluene e321 0,05 mg. excipient qsp 1 pipette 0,5 ml.
Frontline Combo Spot-On Cat Dog S : fipronil 67 mg. s -methoprene 60.3 mg. butylhydroxyanisole e320 0.13 mg. butylhydroxytoluene e321 0.07 mg. excipient qsp 1 pipette of 0.67 ml.
Frontline Combo Spot-On Cat Dog M : fipronil 134 mg. s -methoprene 120.6 mg. butylhydroxyanisole e320 0.27 mg. butylhydroxytoluene e321 0.13 mg. excipient qsp 1 pipette of 1.34 ml.
Frontline Combo Spot-On Cat Dog L : fipronil 268 mg. s -methoprene 241.2 mg. butylhydroxyanisole e320 0.54 mg. butylhydroxytoluene e321 0.27 mg. excipient qsp 1 pipette of 2.68 ml.
Frontline Combo Spot-On Cat Dog XL : fipronil 402 mg. s -methoprene 361.8 mg. butylhydroxyanisole e320 0.80 mg. butylhydroxytoluene e321 0.40 mg. excipient qsp 1 pipette of 4.02 ml.